Saulo aims to quantify how shape, elasticity and physical activity determine musculoskeletal function in healthy and pathological adults. He has pioneered computer methods for studying the neuro-muscle control system, quantifying the risk of bone fracture and informing exercise prescription in osteoporosis. He has optimized joint stability and strength in innovative joint replacements and developed computer technologies for conducting virtual trials of orthopaedic devices. He has also contributed to the development of software for integration clinical imaging toward a personalized, physics-based, medicine.